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Did you try the unsigned 64bit XP driver posted on their site? Try installing it in compatibility mode, too.
www.artlebedev.com/everything/optimus-mini/downloa...
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I got it working in Windows 7 64 bit. Here's what I did:
1. Delete and uninstall any drivers you've installed by selecting the device in device manager -- -- Prolific USB-to-Serial Comm Port (should have an exclamation mark on it)
2. Download the PL2303 Prolific DriverInstaller v1.5.0.zip (and extract it somewhere). You can get it here: www.prolific.com.tw/eng/downloads.asp?ID=31
3. Right click on the PL2303_Prolific_DriverInstaller_v1.5.0.exe
4. Choose "Run as Administrator" and follow the install as usual (should work when finished)
1. Delete and uninstall any drivers you've installed by selecting the device in device manager -- -- Prolific USB-to-Serial Comm Port (should have an exclamation mark on it)
2. Download the PL2303 Prolific DriverInstaller v1.5.0.zip (and extract it somewhere). You can get it here: www.prolific.com.tw/eng/downloads.asp?ID=31
3. Right click on the PL2303_Prolific_DriverInstaller_v1.5.0.exe
4. Choose "Run as Administrator" and follow the install as usual (should work when finished)
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