Purchased an Incredible for myself and one for my wife at launch and we've been really happy with it.
I haven't had any issues but I do recall my wife's Incredible having issues with text messages going to the wrong person. It was rare but after a couple times I went ahead and did a hard reset on her phone and she hasn't had the issue again. Still feels as fast as when I got it but I keep mine pretty clutter free. Only widget I use is the main clock/weather widget and I never use the animated background.